The University of Texas Southwestern (UTSW) campus has grown in all health sectors related to academic research, teaching, inpatient and outpatient care. The north and west sections of the campus have been developed based off a comprehensive campus master plan, co-locating all of patient care services to this area of the campus. The development of this growth is partially completed as outpatient clinics over a period time are relocating into these new structures. The south campus has been designated for academic research, faculty offices, and teaching facilities repurposing and modernizing existing structures within the original sections of the campus. The existing structure on the south campus was first completed in late 1980s with an addition of a parking garage and additional floors in mid-90s. The 150,000 gross square foot interior of the building consisted of a variety of outpatient clinics.

During the summer of 2018, 20% of the outpatient clinics relocated to the west campus; allowing for the opportunity to modernize and expand the remaining clinics, offices, and clinical research units that will continue to reside in Aston for the next 10-15 years, rebranding the Aston building for the O’Donnell Brain Institute. One of the main guiding principles for the project was to improve the delivery of patient care and provide for advances in research and innovation. The lobby level as well as other public areas of the building consist of high level renovation improving wayfinding and updating interior finishes that are clean and crisp with improved lighting for the spaces to feel larger and airy. The renovation of the clinic floors included transition of the clinic layout to support multi-disciplinary team care models within a flexible module configuration.