The New York Structural Biology Center serves the region’s large community of structural biologists, offering training and access to an unparalleled collection of cryo-electron microscopes and high-field NMR spectroscopy. Members of the consortium of major research institutions include: Albert Einstein College of Medicine; The City University of New York; Columbia University; Icahn School of Medicine at Mount Sinai; Memorial Sloan Kettering Cancer Center; Mount Sinai School of Medicine; New York University; Wadsworth Center; and Weill Cornell Medical College.

Davis Brody Bond, a Page company has been working on this world-class facility for cryogenic electron microscopy and ultra-high-field NMR spectroscopy for twenty years. The buildings provide optimized environmental conditions for these sensitive instruments. Select projects to update and expand NYSBC’s main facility at City College have included:

• Peer Review and subsequent upgrades of the Center’s Phase 1 and Phase 2 Buildings for high field NMR Spectroscopy (32,000 Square Feet)
• Phase 3 New Building for Cryo-Electron Microscopy (17,400 Square Feet; 2006)
• Laboratory Renovations for Protein Production and NMR Protein Characterization (3,000 Square Feet; 2010)
• Phase 3 Building Upgrades for next generation Cryo-Electron Microscopes (2016)
• Phase 3 Building Addition to accommodate the Simons Electron Microscopy Center (5,400 Square Feet; 2020)

Building features include heavy foundations for vibration isolation in addition to active vibration isolation platforms; special temperature and humidity controls; active EMF shielding; UPS systems; and desiccant wheel energy recovery systems. The recent Phase 3 Addition brings the total number of electron microscopes at the Center to 13, and significantly increases space for offices, meeting rooms, team workstations and control rooms. Current instrumentation includes: seven Titan Krios Cryo-Electron Microscopes; a FEI Tecnai T12 BioTWIN TEM; a JEOL JEM-1230 TEM; a Thermo Scientific Glacios Cryo-TEM; a FEI Tecnai F20 TEM; a FEI Helios 650 Focused Beam – Scanning Electron Microscope (FIB-SEM); a Hitachi 7800 TEM Screening Microscope; a 500 MHz UltraShield ; a 600 MHz Ascend wide bore; a 700 MHz UltraStabilized; a 750 MHz UltraStabilized wide bore; a 800 MHz UltraShield; two 800 MHz US2; 900 MHz UltraStabilized; and a 900 MHz US2.